Aspects of human exposure to polychlorinated biphenyls

by Gian Marco Currado

Publisher: University of Birmingham in Birmingham

Written in English
Published: Downloads: 950
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Edition Notes

Thesis (Ph.D) - University of Birmingham, Institute of Public and Environmental Health, School of Chemistry, Faculty of Science.

Statementby Gian Marco Currado.
ID Numbers
Open LibraryOL18555411M

  PCB’s or Polychlorinated biphenyls to give them their full title are stable man-made organic compounds that have been in use since the ’s. They can be found in paints and cements, flexible PVC coatings of electrical cables and components, pesticides, cutting oils, flame retardants, lubricating oils, hydraulic fluids, and sealants. Human Health For the maximum protection of human health from the potential carcinogenic effects due to exposure of polychlorinated biphenyls through ingestion of contaminated water and contaminated aquatic organisms, the ambient water concentration should be zero based on the non-threshold assumption for this chemical. The primary nonoccupational source of PCB exposure is food, especially fish from contaminated water. Polychlorinated biphenyls (PCBs) are a family of chemicals with varying numbers of chlorine atoms attached in varying positions to two connected benzene rings The National Academies Press. doi: /   Endocrine disruptors are chemicals that may interfere with the production or activity of human hormones. They include dioxins, polychlorinated biphenyls (PCBs), pesticides, pharmaceuticals, and plasticizers such as bisphenol A (BPA) and phthalates. More.

Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environ Health Perspect. (12): –7. 3. Weisglas-Kuperus, N., Vreugdenhil, HJ., Mulder, PG., Immunological effects of environmental exposure to polychlorinated biphenyls and dioxins in Dutch school children. Size: KB.   Health status of Japanese and Taiwanese after exposure to contaminated rice oil. Environmental Health Perspectives, 60, – US Department of Health and Human Services, Agency for toxic substances and disease registry. Case studies in environmental medicine: Polychlorinated biphenyls (PCBs) toxicity. Fact Sheet: Sources of Polychlorinated Biphenyls Purpose This fact sheet is intended to help Oregon Department of Environmental Quality (DEQ) project managers and City of Portland stormwater inspectors understand the types of industries, processes, and products that might be potential sources of polychlorinated biphenyls (PCBs).File Size: 91KB. This Focus Issue of Environmental Science & Technology on polychlorinated biphenyls (PCBs) came about in part because of a series of international PCB Workshops that have been held biennially over the last ten years. From the beginning, these workshops focused on human health effects and the toxicology of PCBs, but embraced all aspects of PCB by:

  Polychlorinated biphenyls (PCBs) are still present in the environment, with ongoing exposure in humans, including babies nursed by their mothers. Whereas toxicity of dioxin-like PCBs is well described, less systematic knowledge is available for non–dioxin like PCBs (NDL-PCBs) that do not act via the Ah by:

Aspects of human exposure to polychlorinated biphenyls by Gian Marco Currado Download PDF EPUB FB2

Get this from a library. Polychlorinated biphenyls: human health aspects. [Obaid Faroon; World Health Organization.; United Nations Environment Programme.; International Labour Organisation.; Inter-Organization Programme for the Sound Management of Chemicals.; International Program on Chemical Safety.;] -- This book evaluates the effects of.

Polychlorinated biphenyls: Human health aspects. (Concise international chemical assessment document ; 55) lorinated biphenyls - toxicity lorinated biphenyls - adverse effects. assessment nmental exposure ational Programme on Chemical.

Polychlorinated biphenyls and human health Article Literature Review (PDF Available) in International Journal of Occupational Medicine and Environmental Health 11(4) February   This public health statement tells you about polychlorinated biphenyls (PCBs) and the effects of exposure.

The Environmental Protection Agency (EPA) identifies the most serious hazardous waste sites in the nation. These sites make up the National Priorities List (NPL) and are the sites targeted for long-term federal cleanup activities.

The Third Biannual International PCB Workshop / Linda S. Birnbaum --Trends of PCB congener patterns in Japanese environmental media, food, breast milk, and blood in view of risk assessment / Takeshi Nakano, Yoshimasa Konishi, and Rie Masho --Chiral polychlorinated biphenyls and their metabolites / Charles S.

Wong --The importance of atmospheric. Eating PCB-contaminated fish can be a major source of exposure. Exposure from drinking water or from breathing outdoor air containing PCBs is less common.

Once in the air, PCBs can be carried long distances — they have even been found in snow and seawater in the Antarctic. Contaminated indoor air may also be a major source of human exposure.

Polychlorinated biphenyls (PCBs) are a family of industrial chemicals that were produced in the United States from to and used primarily as insulating fluids in capacitors, transformers, and other electrical Size: 1MB. Primary route of exposure to PCBs in the general population -The chlorination pattern of the PCBs is important for the toxicity of the substance.

-The major source of ambient exposure to PCBs is environmental cycling of PCBs previously released into the environment. Caroline M. Tanner, in Blue Books of Neurology, POLYCHLORINATED BIPHENYLS. Polychlorinated biphenyls (PCBs) were used extensively in industrial applications as coolants and lubricants, but their manufacture was stopped in the United States in because of evidence of environmental accumulation of these environmentally persistent compounds.

PCB exposure in. measured for potential or possible exposure in a wide variety of systems – various aspects of the environment, food sources, and human and animal body fluids – and in each case, PCB levels have declined. PCBs in the environment and animals (wildlife) have dramatically and consistently declined over the years.

Polychlorinated biphenyls, in short PCBs, are a Aspects of human exposure to polychlorinated biphenyls book of man-made chemicals. PCBs have been used in many different products, including electrical equipment, surface coatings, inks, adhesives, flame-retardants, and may be released into the environment, for instance when waste that contains PCBs is incinerated or stored in landfills.

Polychlorinated Biphenyls (PCBs): Routes of Exposure and Effects on Human Health Article Literature Review (PDF Available) in Reviews on environmental health 21(1).

A polychlorinated biphenyl (PCB) is an organic chlorine compound with the formula C 12 H 10−x Cl lorinated biphenyls were once widely deployed as dielectric and coolant fluids in electrical apparatus, carbonless copy paper and in heat transfer fluids.

Because of their longevity, PCBs are still widely in use, even though their manufacture has declined drastically since the Chemical formula: C₁₂H10−xClₓ. What are polychlorinated biphenyls. Polychlorinated biphenyls (PCBs) are a group of manmade chemicals.

They are oily liquids or solids, clear to yellow in color, with no smell or taste. PCBs are very stable mixtures that are resistant to extreme temperature and pressure.

PCBs were used widely in electrical equipment like capacitors and. Commercial mixtures of congeners of polychlorinated biphenyls (PCBs) were manufactured starting in the s in Austria, France, Germany, Italy, Japan, Spain, Poland, the Russian Federation, the United Kingdom, and the USA.

No published epidemiological studies of cancer among PCB-production workers were available to the Working Group.

Prenatal exposure to polychlorinated biphenyls: effects on birth size and gestational age. J Pediatr. Aug; (2)– Gladen BC, Rogan WJ, Hardy P, Thullen J, Tingelstad J, Tully M. Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk.

J by: The human exposure routes from hydrocarbons in the environment include inhalation, ingestion, and dermal adsorption. The pathways of exposure can include direct contact with the hydrocarbon phase itself, inhalation of hydrocarbon vapors in indoor or outdoor air, and ingestion of contaminated food or water (Figure 7).Among children, ingestion of contaminated soils also is.

ogy on polychlorinated biphenyls (PCBs) came about in part because of a series of international PCB Workshops that have been held biennially over the last ten years. From the beginning, these workshops focused on human health effects and the toxicology of PCBs, but embraced all aspects of PCB research.

The Workshops created an opportunity for. Occupational exposure to polychlorinated biphenyls (PCBs) shall be controlled so that no worker Is exposed to PCBs at a concentretlon greater than mlcrogram total PCBs per cubic meter of air ( jig/cu m), determined as a time-weighted average (TWA) concentration, for up to a hour workday, hour workweek.

Carcinogenicity Assessment for Lifetime Exposure. Substance Name — Polychlorinated biphenyls (PCBs) CASRN — Last Revised — 10/01/ Section II provides information on three aspects of the carcinogenic assessment for the substance in question; the weight-of-evidence judgment of the likelihood that the substance is a humanFile Size: KB.

Polychlorinated biphenyl (PCB), any of a class of organohalogen compounds prepared by the reaction of chlorine with biphenyl.A typical mixture of PCBs may contain over compounds and is a colourless, viscous mixture is relatively insoluble in water, is stable at high temperatures, and is a good dielectric (electrical insulator).

Because of these qualities, PCBs. Polychlorinated biphenyls (PCBs) are a mixture of chemicals. Some congeners of the mixture are highly persistent both in the environment and in humans. Although PCBs have not been used commercially since about in the US, they can still be detected in human blood and tissues in this country.

PCB levels are declining and are often no longer detectable in Cited by: Polychlorinated biphenyls (PCBs) are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals. Not all PCB mixtures caused tumors in experimental animals.

Cancer Studies in Experimental Animals Oral exposure to PCBs caused liver tumors in mice and rats. In maleFile Size: KB. Development after Exposure to Polychlorinated Biphenyls and Dichlorodiphenyl Dichloroethane Transplacentally and Through Human Milk.

Journal of Pediatrics Guillette, EA, MM Meza, MG Aquilar, AD Soto, and IE Garcia. PCB Exposure and Effect on Learning and Brain Cells In one of the three new studies, exposures to low doses of PCBs in animals hampered their ability to learn to swim a maze, a common test of. environmental media that may be sources of human exposure.

Human Exposure Pathways and Body Burdens Occupational exposure to PCBs may occur through inhalation and dermal contact at workplaces where PCBs are still present (e.g., handling PCB containing electrical equipment, spills or waste-site materials) (HSDB, Exposure to Organo-Chlorinated Compound, PolyChlorinated Biphenyl (PCB), environmental and public health Implications: A Nigeria Case study Michael P.

Okoh Abstract Nigeria faces the challenge of organic waste, which is imported into the country. These wastes cause serious menace to human health, and environment, with reverberation, further : Michael P. Okoh. TABLE OF CONTENTS INTPODUCTION POLYCHLORINATED BIPHENYLS. History of PCB Usage 1 PCB Use Restrictions and Government Regulations 5 CONTRACT SUPPORT OF EPA ACTIONS ON PCRS 7 Support of Office of Toxic Substances 7 Support of the Criteria and Standards Division 10 Support of PCB Work.

Blood serum concentrations of polychlorinated biphenyls (PCBs) were measured in members of a residential community who lived near a chemical plant that formerly manufactured PCBs. Elevated blood serum PCB concentrations were detected in some of the older adults who were long-term residents of the community.

Congener-specific analyses indicated that PCB Cited by: Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading it as a PDF.

Visit to get more information about this book, to buy it in print, or to download it as a free PDF. Occupational exposure to polychlorinated biphenyls in electrical workers. The toxicity of polychlorinated biphenyls doses of PCBs induce liver damage in non-human primates and in rodents In monkeys, depending ondoseandmodeofadministration, acne,alopaecia, hyperpigmentationofthe skin, thymicatrophy, ocu- Cited by: Polychlorinated Biphenyls: the Background PCB is the commonly used abbreviation for a group of organochlorine compounds referred to as polychlorinated biphenyls or polychlorobiphenyls [1].

These materials, represented by the general structure shown in Figure 1 and the formula C 12H 10–xCl x, are based structurally on aFile Size: KB.EXPOSURE TO DIOXINS AND DIOXIN-LIKE SUBSTANCES: A MAJOR PUBLIC HEALTH CONCERN. Human exposure to dioxins and dioxin-like substances has been associated with a range of toxic effects, including immunotoxicity, developmental and neurodevelopmental effects, and Polychlorinated biphenyls: Human health aspects.

Geneva, World Health.